Talk to your doctor about the risks and benefits of this medication. *T0T0 Bf Examples include azole antifungals (such as ketoconazole), bupropion, fluoxetine, macrolide antibiotics (such as erythromycin), paroxetine, quinidine, rifamycins (such as rifabutin, rifampin), ritonavir, certain drugs used to treat seizures (such as carbamazepine, phenytoin), among others. $17.46 $ 17. The main intended feature of the special chemical compound in the delay spray is to desensitize the penis, so one might be able to encounter Benzedrex is an over-the-counter nasal spray that it is abused by a surprising portion of the population. We would like to show you a description here but the site won't allow us. The adverse effects varied in severity. [1], Denatonium also discourages consumption of poisonous alcohols such as methanol and additives such as ethylene glycol. 1-833-TMELITE; FAQs; Contact Us; Home; Trademark Service. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. test conductor shall spray the Threshold Check Solution into the enclosure. Tell your doctor if you are pregnant or think you may be pregnant. Things to remember when you fill your prescription. However, be sure to see a healthcare provider if you think you may be experiencing any. endstream Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. This survey is being conducted by the WebMD marketing sciences department. Tell your doctor or pharmacist right away if you have withdrawal. Does Btrex Oral interact with other medications? 13.1 One spray is enough. dizziness. bitrex spray side effects. This patent application was filed with the USPTO on Friday, March 21, 2014. Benzocaine products carry a number of side effects other than methemoglobinemia. x+r flushing or redness of the skin. Seller does not accept returns. 12 Medicines That Could Help. If you have any condition related to your adrenal glands, such as Addison's disease, it is possible for nasal steroid sprays to make them worse. Burning or stinging. Imitrex Nasal Spray Patient Information is supplied by Cerner Multum, Inc. and Imitrex Nasal Spray Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights. Blistering, burning, crusting, dryness, or flaking of the skin. Consult your pharmacist or local waste disposal company. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. This document does not contain all possible drug interactions. Imitrex Nasal Spray (Sumatriptan Nasal Spray) , Ear, nose, and throat Disorder/discomfort of. You can lessen this effect by using the spray after showering or placing your head over a steamy sink for 5 to 10 minutes. Talk to your doctor if you are using marijuana (cannabis). The unique formulation is packaged in an atomizer bottle, allowing owners to spray the product on things their dogs seem to be drawn to lick or chew. Dizziness or drowsiness can cause falls, accidents, or severe injuries. *T0T0 Bf This reaction required heating the substrates to 110C (230F) for 35 hours. Learn How Genetics Make Some Fans of Fear, Dr. Whyte's Book: Take Control of Your Cancer Risk, How Breast Cancer Changed My Life and Me, Health News and Information, Delivered to Your Inbox, Treating Opioid Use Disorder With Medications, Constipated? You may report side effects to Health Canada at 1-866-234-2345. What should I know regarding pregnancy, nursing and administering Btrex Oral to children or the elderly? Includes 5 business days handling time after receipt of cleared payment. doi: 10.1542/peds.105.2.e23, Rollema C, Roon EN van, Vries TW de. You may report side effects to the FDA at 1-800-FDA-1088. The objective of this investigation was to prepare mucoadhesive microspheres of ketorolac for nasal delivery to avoid gastrointestinal side effects of conventional dosage form. It is also possible that an overabundance of the IGF-1 in deer antler spray will create side effects similar to excessive amounts of human growth hormone, though no study has backed this theory up. At any given time, about 10% of those female workers of child-bearing age (1544 years of age) will be pregnant. endobj Most claims involved respiratory symptoms and 3 dermatitis or angioedema symptoms. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Do not feed it to your baby. We understand how the rough and tumble of family life works. By Daniel More, MD someone accused me of scratching their car, Five Heritage Sites In Zimbabwe And Their Importance, chief constable lancashire police email address. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Take the Taste Test and see for yourself. It may harm an unborn baby. View Alerflo Nasal Spray (bottle of 6 gm Nasal Spray) uses, composition, side-effects, price, substitutes, drug interactions, precautions, warnings, expert advice and buy online at best price on 1mg.com Selected from data included with permission and copyrighted by First Databank, Inc. Ask your doctor or pharmacist about other ways to relieve cough and cold symptoms, such as drinking enough fluids, using a humidifier, or saline nose drops/spray. Can be used to check face-to-respirator seal on any particulate respirator or gas/vapor respirator with a particulate prefilter. They do not affect other parts of your body unless you use too much. Irritability. [8], The bitterness of the compound guides most applications of denatonium. Call your doctor for medical advice about side effects. See also Warning section. Most accidental poisonings happen when products are in use. Be sure you know how to take this product and what other drugs you should avoid taking with it. The researchers note that improper technique when using a nasal spray can raise your risk of nosebleed or a perforated septum. Denatonium benzoate is used to denature ethanol so that it is not treated as an alcoholic beverage with respect to taxation and sales restrictions. Nose Breather, Local and systemic safety of intranasal corticosteroids, Intranasal fungal (Alternaria) infection related to nasal steroid spray, Overcoming barriers to intranasal corticosteroid use in patients with uncontrolled allergic rhinitis, Growth velocity reduced with once-daily fluticasone furoatenasalsprayin prepubescent children with perennial allergic rhinitis, Detection of growth suppression in children during treatment with intranasal beclomethasone dipropionate, Inadequate quality of administration of intranasal corticosteroid sprays, Clinical practice guideline: allergic rhinitis. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Do not freeze liquid forms of this medication. Now, reaction time can be reduced to two hours at 82C (180F) by using acetonitrile as solvent and potassium iodide as catalyst. If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Table 1: Adverse Reactions Reported by at Least 1% of Patients and at a Greater Frequency than Placebo in Controlled Migraine Clinical Trials. Do not start, stop, or change the dosage of any medicines without your doctor's approval. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Any time that hormones are fluctuating mood changes, anxiety, depression, and exacerbation of PMS symptoms can result. The side effects of decongestant sprays can leave you feeling worse than when you started. Select a condition to view a list of medication options. Cough due to a common cold often does not need to be treated with medicine. Head Office, Macfarlan Smith, 10 Wheatfield Road, Edinburgh, EH11 2QA, This medication may also cause severe, possibly fatal, breathing problems. Steroid nasal sprays are not the same as anabolic steroids, drugs that some people use to encourage muscle building. bitrex spray side effects. All rights reserved. Some liquids need to be shaken before pouring each dose. Sumatriptan is a white to off-white powder that is readily soluble in water and in saline.Each IMITREX Nasal Spray contains 5 or 20 mg of sumatriptan in a 100-L unit dose aqueous buffered solution containing monobasic potassium phosphate NF, anhydrous dibasic sodium phosphate USP, sulfuric acid NF, sodium . The active ingredient is effective against EYE CONTACT: May cause mild eye irritation. This patent application was filed with the USPTO on Friday, March 21, 2014 burning or aching pain in your feet or toes while resting. There were insufficient data to assess the impact of race on the incidence of adverse reactions. Drink plenty of fluids while you are using this medication unless otherwise directed by your doctor. This section applies to General Industry (part 1910), Shipyards (part 1915), Marine Terminals (part 1917), Longshoring (part 1918), and Construction (part 1926). Once you start looking, you'll be amazed how many products contain Bitrex. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. It won't make you sick or ill, it just tastes so bitter that you will want to spit it out - fast. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. endobj 17) These sprays do NOT offer any protection against STI. This combination medication is used to temporarily treat coughing and chest congestion symptoms caused by the common cold, flu, or other breathing illnesses (such as sinusitis, bronchitis). WebMD does not provide medical advice, diagnosis or treatment. with perch stand. Bitter Apple takes its flavoring from what is known as extract of bitters.. In fact, the list of side effects for the most popular ingredient in nasal sprays, Fluticasone, comes with a litany of unwanted issues. J Investig Allergol Clin Immunol. Point the tip to the back/outer side of your nose upon insertion. If you have bleeding and irritation of your nasal passages, it can increase your risk of more serious complications. These drugs work by limiting the amount of allergens and other irritants that enter the moist lining of your sinus passages, called mucosa. nasal spray. Lee LA,Sterling R,Mspero J,Clements D,Ellsworth A,Pedersen S. Growth velocity reduced with once-daily fluticasone furoatenasalsprayin prepubescent children with perennial allergic rhinitis. They received either beclomethasone dipropionate (BDP) spray for their allergy symptoms or a fake treatment (placebo). Please contact your doctor or pharmacist. Also, other medications can affect the removal of this product from your body, which may affect how it works. The bitterest substance known to man, woman or child. 16 Surprising Headache Triggers and Tips for Pain Relief. A very serious allergic reaction to this drug is rare. For the moments of inattention when most accidents happen. [5], One of the chemical names for the compound is lidocaine benzylbenzoate, although denatonium only denotes the quaternary ammonium cation species itself, and does not necessitate the benzoate counterion. Less common. When taken properly, it has a very low potential for abuse, but it is often used recreationally via oral and intravenous administration. What to Know About Steroid Nasal Spray Side Effects. Sniffles (Nasal Congestion and Discharge), An Overview of Afrin Nasal Spray (Oxymetazoline), The Connection Between Nasal Polyps and Sinus Infections, Sinus Surgery: Everything You Need to Know, Functional Endoscopic Sinus Surgery: Everything You Need to Know, What Thyroid Patients Need to Know About Decongestants. Take this medication by mouth with or without food, usually every 4 to 6 hours as needed with a full glass of water (8 ounces or 240 milliliters) or as directed by your doctor. 25P04RIr Thank you, {{form.email}}, for signing up. But it packs a hell of a puncha single molecule of Bitrex can make a million molecules of water taste horrible. *T0T0 Bf It is also added to less hazardous aerosol products (such as gas dusters) to discourage inhalant abuse of the volatile vapors. Otherwise, call a poison control center right away. This is not a complete list of side effects and others may occur. Talk with your doctor if this medication stops working well. Nasal steroid spray can cause irritation, redness, and other symptoms in and around your nose. Denatonium, usually available as denatonium benzoate (under trade names such as Denatrol, BITTERANT-b, BITTER+PLUS, Bitrex, Bitrix, and Aversion) and as denatonium saccharide (BITTERANT-s), is the most bitter chemical compound known, with bitterness thresholds of 0.05ppm for the benzoate and 0.01ppm for the saccharide. [13], InChI=1S/C21H28N2O.C7H6O2/c1-5-23(6-2,15-19-13-8-7-9-14-19)16-20(24)22-21-17(3)11-10-12-18(21)4;8-7(9)6-4-2-1-3-5-6/h7-14H,5-6,15-16H2,1-4H3;1-5H,(H,8,9), InChI=1/C21H28N2O.C7H6O2/c1-5-23(6-2,15-19-13-8-7-9-14-19)16-20(24)22-21-17(3)11-10-12-18(21)4;8-7(9)6-4-2-1-3-5-6/h7-14H,5-6,15-16H2,1-4H3;1-5H,(H,8,9), [O-]C(=O)c1ccccc1.Cc2cccc(C)c2NC(=O)C[N+](CC)(CC)Cc3ccccc3, Except where otherwise noted, data are given for materials in their, Structure, synthesis, and physical properties. Terms & Conditions To be honest, they are not. endstream Check the labels on all your medications carefully to make sure you are not taking more than one product that contains guaifenesin. 2014;2(4):421-7. doi:10.1016/j.jaip.2014.04.008. Common side effects of Imitrex Nasal Spray include: mild headache (not a migraine), pressure or heavy feeling in any part of your body, feeling hot or cold, dizziness, spinning sensation, drowsiness, nausea, vomiting, drooling, unusual taste in your mouth after using the nasal spray, If you notice other side effects not listed above, contact your doctor or pharmacist. Using the nebulizer labeled BITREX Fit Test Solution, inject the. 1Pc Parrot weight s Plaqueoff 180g - Reduce Plaque and Tartar - Pets & Animals / Dogs, Puppies PlaqueOff Powder is a pet dental product for both cats and dogs. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). dry skin. itching. Other side effects include: asthenia, burning sensation, chest discomfort, neck pain, neck stiffness, numbness, throat irritation, feeling of heaviness, flushing, sensation of pressure, and sensation of tightness. required as was necessary to elicit a response in the threshold. runny or stuffy nose after using the nasal medicine. Borax affects hormones. Last reviewed on RxList: 8/23/2022 Special financing available. Frequent use of hair spray can lead to difficulty in breathing. dizziness. chills or shaking redness of your face (flushing) itching or rash shortness of breath, cough, or wheezing swelling of your lips, tongue, throat, or face dizziness feel like passing out tiredness fever feel like your heart is racing (palpitations) Each ampoule provides enough solution for between 3-5 tests. This drug may make you dizzy or drowsy. itching, scaling, severe redness, soreness, or Also, it is used to prevent infections. [citation needed], In 1995, the U.S. state of Oregon required that denatonium benzoate be added to products containing sweet-tasting ethylene glycol and methanol such as antifreeze and windshield washer fluid to prevent poisonings of children and animals. Eye Contact: Contact with the eyes during product use is not expected to result in significant irritation. Consult your doctor or pharmacist about using this medication safely. Drug interactions may change how your medications work or increase your risk for serious side effects. Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Oxum Spray Uses in Hindi | Side Effects | Dose-----Related SearchesOxum Spray Uses in HindiOxum Spray Use in HindiOxum Spray K. endstream Flutiways Nasal Spray , - Flutiways Nasal Spray Side Effects in Hindi . Spray apparatuses, uses of diatomaceous earth, and methods of controlling insect populations is an invention by Roderick William Phillips, Vancouver CANADA. Disadvantages and side effects of Delay Spray in India 1. doi:10.1177/0194599814561600. You can avoid these side effects by knowing the correct way to use the spray and applicator. headache. Jurairat J. Molina, MD, MBA is a board-certified allergist who has been practicing in field of allergy and clinical immunology for the past two decades. as others have said, the denaturing adds some sort of chemical to make the stuff undrinkable and some aditives may be worse than others. sudden and severe stomach pain and bloody diarrhea; severe chest pain, shortness of breath, irregular heartbeats; severe headache, blurred vision, pounding in your neck or ears; pain or tight feeling in your chest, throat, or jaw; pressure or heavy feeling in any part of your body; numbness or tingling, feeling hot or cold; unusual or unpleasant taste in your mouth after using the nasal medicine; pain, burning, numbness, or tingling in your nose or throat after using the nasal medicine; or. Valtoco side effects Get emergency medical help if you have signs of an allergic reaction to Valtoco: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Skoner DP, Rachelefsky GS, Meltzer EO, Chervinsky P, Morris RM, Seltzer JM, et al. Do not use it later for another condition unless told to do so by your doctor. Nomenclature: Bitrex Fit Test Solution # 2 H 1 Company Name: Allegro Industries F 1 Address: 7221 Orangewood Avenue R 1 Garden Grove, CA 92841 O None 714-899-9855 Chemtrac: 800-424-9300 2. Look for the logo when youre shopping, and only choose products that contain Bitrex. *T0T0 Bf 6. Get medical help right away if any of these very serious side effects occur: slow/shallow breathing, unusual lightheadedness, severe drowsiness/ dizziness, difficulty waking up. Terms & Conditions If you notice some kind of pain or unbearable sensations then dont use it or dial down the dose. Bitrex solution molecule size. Extreme temperatures may affect viscosity but will not affect product performance. Frank ME, Bouverat BP, MacKinnon BI, Hettinger TP. 16 0 obj *T0T0 Bf This medicine is available only with your doctor's prescription. 6. They help calm your body's response to these irritants, reducing swelling and mucus. Sneezing. unusual dreams. <>stream These are the hollow spaces in your head that connect with the passages in your nose. cracking or tightening of the skin. Though it helps many people, this product has a risk for abuse and may sometimes cause addiction. 25P04RIr Overcoming barriers to intranasal corticosteroid use in patients with uncontrolled allergic rhinitis. vial. endstream 2 0 obj MSA 697446 Replacement Fit Test Solution for Bitrex Qualitative Fit-Test Kit, Easy-to-Use, Effective & Efficient Safety System Gear, Used for Reusable Respiratory Protection Device . Due to the lighting effects, monitor settings, etc. What are the side effects of Biotene Moisturizing Mouth Spray (Saliva Substitutes)? Championing the use of Bitrex in as many household products as we can. Availability: Special Order item, call customer service to order. The Threshold Check Solution is prepared by adding 13.5 milligrams of Bitrex to 100 ml of 5% salt (NaCl) solution in distilled water. If you notice some kind of pain or unbearable sensations then don't use it or dial down the dose. In fact, The Guinness World Records lists Bitrex as the most bitter substance in the world.. For some, steroid nasal spray use may be either carefully considered or outright inadvisable, as they are at greater risk for side effects than others. Material Safety Data Sheet Denatonium benzoate sc-234525 Hazard Alert Code Key: EXTREME HIGH MODERATE LOW Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION Get medical help right away if you have any very serious side effects, including: seizure. [citation needed], Denatonium is commonly included in placebos used in clinical trials to mimic the bitter taste of certain medications. Better known as steroid nasal sprays, these drugs come in liquid form that is misted into the nostril. Excessive use of the delay spray can cause temporary sensitivity loss and possibly the loss of an erection for a short period of time. 13.2 Will buy more bottles. In eyes. Denatonium, usually available as denatonium benzoate (under trade names such as Denatrol, BITTERANT-b, BITTER+PLUS, Bitrex, Bitrix, and Aversion) and as denatonium saccharide (BITTERANT-s), is the most bitter chemical compound known, with bitterness thresholds of 0.05 ppm for the benzoate and 0.01 ppm for the saccharide. Treatment may include reducing the dose or stopping the . Burning or stinging of the skin. During pregnancy, this medication is not recommended. Common steroid nasal spray side effects include: Local side effects of steroid nasal sprays tend to affect the nasal passage openings most. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. x+r Scotland, United Kingdom, Tel: +44 (0)131 337 2434 Stud 100 has been through clinical trials that proved it is safe when used in right amounts. 0.5ml of 6mg/0.5ml. Older adults may be more sensitive to the side effects of this drug, especially confusion, dizziness, drowsiness, and slow/shallow breathing. Dysphonia (harsh voice) This can be caused by irritation of the mucous lining in your larynx, by "myopathy of laryngeal muscles," or by laryngeal thrush. [6][7], Denatonium can act as a bronchodilator by activating bitter taste receptors in the airway smooth muscle. * To learn more How bitter is Bitrex? There has been some concern about hyperactivity, irritability, or behavioral problems in children who regularly use nasal steroid sprays. It is a compound of a salt with an inert anion such as benzoate or saccharinate. Also, tell your doctor if your condition gets worse, or if you have a headache that doesn't go away, fever, or rash. Host a Taste Test and help us spread the word about Bitrex. spray. Despite the best efforts of parents to keep them safe, young children have a natural - and maddening - tendency to bite, taste or chew the objects around them. Intranasal fungal (Alternaria) infection related to nasal steroid spray. Check with your doctor immediately if any of the following side effects occur while taking oxymetazoline nasal: Blurred vision. Examples include: Others are available over the counter (OTC), including: Nasal steroid sprays are mainly used to treat congestion and symptoms caused by allergies and chronic sinusitis. Wash the affected area thoroughly with soap and warm water. The primary side effect is temporary penis desensitization. I was having chest pain this morning, when the paramedics came she gave me the gtn spray but before that she gave me an orange flavoured tablet to chew, does anyone know what this was, I didn't get any side effects from the spray and wondered if it was the tablet I took before it. EYE CONTACT: May cause mild eye irritation. Although the study did not examine specific products, it is a good idea to choose cleaners . Keeping our children safe is our most important role as adults. By clicking Accept All Cookies, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. Ingestion: No known health effects. Alerflo Nasal Spray is used in the treatment of Sneezing and runny nose due to allergies,Severe allergic reactions,Skin conditions with inflammation & itching. SKIN CONTACT: Prolonged skin contact may cause mild irritation. (a) Permissible practice. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox, Treating Opioid Use Disorder With Medications, Constipated? fit test aerosol into the hood. Denatonium is used in denatured alcohol,[3] antifreeze, preventive nail biting preparations, respirator mask fit-testing, animal repellents, liquid soaps, shampoos, and Nintendo Switch game cards to prevent accidental swallowing or choking by children. That's especially true if you have just started using nasal steroid sprays for allergies. Taking this medication with alcohol or other drugs that can cause drowsiness or breathing problems may cause very serious side effects, including death. After all that time, it's still the best for keeping bugs at bay. But some do. Keep products out of reach of children. Children are at higher risk for serious (even fatal) side effects, especially breathing problems. [1] To name a few common side effects: Bloody nose; Fever; Headache; Muscle Aches; Sore Throat; Troubled Breathing . cold feeling or color changes in 1 or both legs or feet. If youre looking to buy a good delay spray then its right here. For more information, you can refer to Xareltos medication guide. Side effects may include any of these symptoms: Dryness, burning, or stinging in the nasal passage. Call your doctor for medical advice about side effects. Care Plus Anti-insect Deet Spray 40% - Care Plus DEET is the strongest insect-repellent remedy for the skin. Tell your doctor if your cough does not get better in 5 days. J Investig Allergol Clin Immunol. These include breaks in the skin (ulceration)or small holes (perforation) in the septum, found between your nostrils. 19 0 obj Decreased Pleasure. Sharing safety tips to help you protect your children from accidental poisoning. Always keep products in their original containers and use the child safety features correctly. Don't believe us? Medical Editor: John P. Cunha, DO, FACOEP. Drowsiness, dizziness, lightheadedness, facial flushing, nausea, vomiting, or constipation may occur. Toxicological Data 5. % Fax: +44 (0)131 337 9813, Home Cases of serotonin syndrome have been reported during coadministration of triptans and SSRIs, SNRIs, TCAs, and MAO inhibitors [see WARNINGS AND PRECAUTIONS]. Little Remedies Saline Spray Drops For Noses All Ages NO Alcohol OR Side Effects. People can experience a wide range of side effects from esketamine therapy. It was discovered in 1958 during research on local anesthetics by MacFarlan Smith of Edinburgh, Scotland, and registered under the trademark Bitrex. Some health conditions can put you at greater risk. If someone accidentally swallows this drug, get medical help right away. Blistering, flaking skin. Using a steroid nasal spray the wrong way can cause side effects, so always follow product instructions. pain, pressure, or tightness in Mild side effects of Xarelto can include: abdominal (belly) pain. 2005 - 2023 WebMD LLC. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. But despite this bitterness, Bitrex is itself totally harmless. It is also added to many kinds of harmful liquids, including solvents (such as nail polish remover), paints, varnishes, toiletries and other personal care items, special nail polish for preventing nail biting, and various other household products.
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bitrex spray side effects